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The space between a sending neuron’s (nerve cell) axon terminal and the receiving nerve cell’s dendrite receptor or the receptor on a muscle cell.  The transmission of a signal from the sending cell is carried out by the release of a neurotransmitter that crosses the cleft to the receiving cell.  The space is estimated at 10 to 20 nanometers across.   A nanometer is one billionth of a meter.  It is also call the synaptic gap.

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